Endocrine Abstracts

Background: Malignant paragangliomas are rare. Predictors of malignant potential include high levels of normetadrenaline and/or dopamine, and the presence of a germline mutation in the succinate dehydrogenase B gene (SDHB). Prognosis is poor and treatment options are limited, with only short-term responses observed after 131I-MIBG therapy or chemotherapy.Aim: To report response to the oral tyrosine kinase inhibitor sunitinib.<p cl...

Background: Cabergoline-associated valvulopathy (CAV) is an established complication of cabergoline therapy in Parkinson’s disease, with a definitive echocardiographic triad of severe regurgitation, leaflet thickening, and restricted valve movement without calcification. Long-term cabergoline therapy is deemed safe for prolactinoma due to low dosage. We describe the first UK case report of aortic regurgitation (AR) associated with low-dose cabergoline in prolactinoma....

Background: Postoperative diabetes insipidus (DI) occurs predominantly following pituitary surgery. Here we present a case of transient DI developing after coronary artery bypass surgery (CABG) and aortic valve replacement and discuss the potential mechanisms.Case Presentation: A 69-year-old female with a past medical history of atrial fibrillation, hypertension and stroke was admitted for elective aortic valve replacement for severe aortic stenosis. The...

Background: The optimum management strategy for primary hyperparathyroidism remains debatable especially in patients with mild or asymptomatic disease. We aimed to compare the baseline characteristics and long-term outcomes of patients with primary hyperparathyroidism who were either managed conservatively or underwent elective parathyroidectomy.Methodology: We carried out a retrospective cohort analysis of patients with primary hyperparathyroidism under...

Introduction: Recent randomised controlled trials have demonstrated the efficacy of very low calorie diets (VLCD) in carefully selected patients with type 2 diabetes mellitus (T2DM). However, there is paucity of evidence regarding the efficacy of VLCD in the real-world setting. We evaluated outcomes in obese T2DM patients who underwent VLCD at our institution.Methods: This retrospective observational study included all patients who had undergone VLCD fro...